| abstract |
Novel, orally active androgens are 7α substituted Δ14-nandrolone derivatives. The compounds satisfy formula (I) wherein R¿1? is O, (H,H), (H,OR), NOR, with R being hydrogen, (C1-6) alkyl or (C1-6) acyl; R2 is selected from the group consisting of (C2-4) alkyl, (C2-4) alkenyl, or (C2-4) alkynyl, each optionally substituted by halogen; or R2 is cyclopropyl, or cyclopropenyl, each optionally substituted by (C1-2) alkyl, or halogen; R3 is hydrogen, (C1-2) alkyl, or ethenyl; R4 is (C1-2) alkyl; R5 is hydrogen, or (C1-15) acyl; and the dotted lines indicate optional bonds. |