abstract |
The invention provides 19-nor-D-homosteroids, having a mixed androgenic/progestagenic profile, which are orally active, prevent trabecular bone mineral density (BMD) loss, and which lack liver toxicity, having a structure according to the formula (I) wherein, R 1 is O, or NOR, with R being hydrogen, (C1-6)alkyl, or (C1-6)acyl, R 2 is methyl or ethyl, and R 3 is hydrogen or (C 1-15 )acyl. |