| abstract |
The invention concerns amide derivatives of Formula (I), wherein: G is N or CH; R1 is a group such as hydroxy, halo, trifluoromethyl, C¿1-6?alkyl and C1-6alkoxy; each of R?2 and R3¿ is hydrogen, halo, C¿1-6?alkyl, C2-6alkenyl or C2-6alkynyl; R?4¿ is a group such as hydrogen, hydroxy, C¿1-6?alkyl, C1-6alkoxy and C3-7cycloalkyl, or R?4¿ is of the Formula (IC): K J, wherein J is aryl, heteroaryl or heterocyclyl and K is a bond or a group such as oxy and imino, R5 is a group such as hydrogen, halo and trifluoromethyl; m is 1-3 and q is 0-4; or pharmaceutically acceptable salts or in vivo cleavable esters thereof; processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or medical conditions mediated by cytokines. |