| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ba56a6a8ffbe755f4b07129786a07941
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_738afb4d6fe3af484a148a43f39c3c4c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_66ca63a838ef4da4967bb7203e5c27fe
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8bd7a45a343acd10e3f5d8775dda2157
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6d8526b670575e676e6f846d4f4f5cf6 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-54393
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-54386
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K17-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N1-405
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57492 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N1-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-543
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K17-14 |
| filingDate |
2012-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2017-01-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_30b1e53821e84ea8586dcc197d52ceb4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_34774fc0f92aa1091c738e55dedf2419
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e51f24a81c371cd3b6d3e62986daca58
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9f865fbe2ebbf8590d08e4658a99d95e |
| publicationDate |
2017-01-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-9541480-B2 |
| titleOfInvention |
Capture, purification, and release of biological substances using a surface coating |
| abstract |
This invention relates to a surface coating for capture circulating rare cells, comprising a nonfouling composition to prevent the binding of non-specific cells and adsorption of serum components; a bioactive composition for binding the biological substance, such as circulating tumor cells; with or without a linker composition that binds the nonfouling and bioactive compositions. The invention also provide a surface coating for capture and purification of a biological substance, comprising a releasable composition to release the non-specific cells and other serum components; a bioactive composition for binding the biological substance, such as circulating tumor cells; with or without a linker composition that binds the releasable and bioactive compositions. The present invention also discloses a novel microfluidic chip, with specific patterned microstructures to create a flow disturbance and increase the capture rate of the biological substance. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11674958-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10107726-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10605708-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10495644-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11175286-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11085071-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10112198-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10759766-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11709156-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11709155-B2 |
| priorityDate |
2011-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |