| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0853f14a64b16d1710f4315d150da980
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_626b266a467c841b8ac7bc29f6a9c0fe
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2bd5156fcb32b973f1442f9782b6a622
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_525a347e0e55f20d1441c6b1186c3039
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_06d09f6ecb5706f855c399574e5bfdb1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_71608064912318c6adbac1628f7102cc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_07bfb5e1695e7981684b19de6669824f |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-552 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-0003
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-04 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00 |
| filingDate |
2012-04-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2015-08-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5acffb23316da897331967bfc50861ca
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8a68af5eafafd348358b6dedad04f80a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1432d0b72a83f8fdca992bb7b6c7eaf7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_69c3eb088e7beab2a3e9c130c489dc64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cb079c5f3f668b0bce86cc35d0784200
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f5042070ac658958b57cba75b5cac3e6 |
| publicationDate |
2015-08-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-9101557-B2 |
| titleOfInvention |
Combination of protein forms for hornfly vaccination |
| abstract |
Thrombostasin is an anti-clotting protein found in saliva of Haematobia irritans . Disclosed herein are studies testing blood uptake of horn flies feeding on cattle which confirm the association of ts genotype with blood uptake of horn flies. Blood uptake volumes of homozygous ts10 horn flies were lower than those of other ts genotypes when fed on control cattle. Cattle vaccinated with recombinant protein isoforms rTS9 or rTB8 resisted horn fly feeding by yielding lower blood volumes compared to flies feeding on control cattle. The impact of vaccination varied by ts genotype of flies. Cattle vaccinated with isoforms rTS9 resisted flies of ts2, ts9, and tb8 genotype. Vaccination with isoforms rTB8 produced resistance to ts8, ts9 and tb8 genotype flies. Horn flies of genotype ts10 were not affected with either TS isoforms and fed well on rTS9 and rTB9 vaccinated as on control-vaccinated cattle. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9724398-B2 |
| priorityDate |
2011-04-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |