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filingDate 2011-03-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2014-11-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6ed17c2a03659577ebaa55ee4b8462f0
publicationDate 2014-11-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-8883450-B2
titleOfInvention Signal peptide, and use thereof for producing recombinant proteins
abstract A use of a signal peptide for producing a recombinant polypeptide of interest in an expression system, the signal peptide includes at least 12 amino acids of formula (I):n n(X1) i X2X3X4SX5X6X7,n nwherein:n X1 is a peptide containing from 3 to 6 amino acids, i equal to 0 or 1, X2 is a peptide containing from 3 to 9 hydrophobic amino acids, X3 is a peptide containing from 3 to 5 amino acids, the peptide including at least 3 contiguous or non-contiguous leucines X4 is a peptide containing from 2 to 5 amino acids chosen from Ala, Thr, Ser, Gln, Ile, Met, X5 is Ala or Val, X6 is Gln, Asn or His, X7 is Ala or Cys,n nprovided that when the signal peptide originates from a natural precursor of a specific protein, the polypeptide of interest is different from the protein.
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