Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2020b07af227d1b3ff1ae4a760e7316f http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_401cb896c0fae1497c548671dd60beda http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_130efb8ab1446af2ced47bb5f1b4b789 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_695c9536527545bae4b258df5ca4176b http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ffe5ad40455d65dd093ae39f4d93208a |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1652 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1611 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2009 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2077 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2054 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-14 |
filingDate |
2009-03-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate |
2014-05-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1ec4fd6c7c1576aa4606509fab55c2a9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7f5672eabd915c62e712e970c1fc2145 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ec5e77d3ea7185bf3ef91dbe955985cf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_24da1250b40ac9f03a9799986c8c1a26 |
publicationDate |
2014-05-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-8722094-B2 |
titleOfInvention |
Solid dispersion and pharmaceutical composition of the same, and production processes thereof |
abstract |
A powdery porous carrier comprising a porous silicon-containing carrier is impregnated with a solution containing an organic solvent and an active ingredient hardly soluble in water, and the organic solvent is removed to give a solid dispersion having the active ingredient supported to the porous carrier without a treatment with a supercritical fluid. The porous silicon-containing carrier has a heating loss of not more than 4% by weight at a temperature of 950° C. for 2 hours (e.g., a spherical silicon-containing carrier such as a spherical porous silica). The porous silicon-containing carrier may be a spherical silica having a mean pore size of 10 to 40 nm and an oil absorption of 175 to 500 ml/100 g. A pharmaceutical composition (e.g., tablets, granules, or capsules) may be prepared from the solid dispersion and a pharmaceutically acceptable carrier. This invention provides a solid dispersion and a pharmaceutical composition (or a pharmaceutical preparation) which allows improvement in a solubility and a bioavailability of an active ingredient hardly soluble in water (e.g., a fibrate compound). |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10835495-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016041992-A1 |
priorityDate |
2008-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |