| abstract |
PURPOSE: To obtain a solid drug for oral administration having properly adjusted absorption and immediate effects or prolonged effects, readily being taken, comprising a drug active compound and silicon dioxide or magnesium aluminate metasilicate. n CONSTITUTION: A solid or liquid drug active compound (e.g. nifedipine) suitable for oral administration is dissolved in an organic solvent (e.g. ethanol). The solution is blended with fine powder of silicon dioxide or magnesium aluminate metasilicate and generally used preparation auxiliaries such as excipient, binder, disintegrator or dispersant properly and granulated or compression molded to give the objective substance. The weight ratio of the drug active compound and silicon dioxide or magnesium aluminate metasilicate is 1:0.5-5 by weight ratio. n COPYRIGHT: (C)1992,JPO&Japio |