| abstract |
Disclosed is a compound useful as a type I 11βhydroxysteroid dehydrogenase inhibitor. n A compound represented by the formula: n n n n n n n n n n a pharmaceutically acceptable salt or solvate thereof, n wherein n R 1 is optionally substituted alkyl or the like, n one of R 2 and R 4 is a group of formula: —Y—R 5 , n wherein Y is —O— or the like, n R 5 is substituted alkyl (the substituent is optionally substituted cycloalkyl or the like), optionally substituted branched alkyl or the like, n the other of R 2 and R 4 is hydrogen or optionally substituted alkyl, n R 3 is a group of formula: —C(═O)—Z—R 6 , n wherein Z is —NR 7 — or —NR 7 —W—, n R 6 is optionally substituted cycloalkyl or the like, n R 7 is hydrogen or optionally substituted alkyl, n W is optionally substituted alkylene, n X is ═N— or the like, n with the proviso that compounds wherein R 2 is 2-(morphorino)ethoxy, R 3 is N-(1-adamantyl)carbamoyl and R 1 is benzyl are excluded. |