| abstract |
Disclosed is a compound useful as a type I 11βhydroxysteroid dehydrogenase inhibitor. nA compound represented by the formula:n na pharmaceutically acceptable salt or solvate thereof, nwherein nR 1 is optionally substituted alkyl or the like, none of R 2 and R 4 is a group of formula: -Y-R 5 , nwherein Y is -O- or the like, nR 5 is substituted alkyl (the substituent is optionally substituted cycloalkyl or the like), optionally substituted branched alkyl or the like, nthe other of R 2 and R 4 is hydrogen or optionally substituted alkyl, nR 3 is a group of formula: -C(=O)-Z-R 6 , nwherein Z is -NR 7 - or -NR 7 -W-, nR 6 is optionally substituted cycloalkyl or the like, nR 7 is hydrogen or optionally substituted alkyl, nW is optionally substituted alkylene, nX is =N- or the like, nwith the proviso that compounds wherein R 2 is 2-(morphorino)ethoxy, R 3 is N-(1-adamantyl)carbamoyl and R 1 is benzyl are excluded. |