| abstract |
α,β-Unsaturated sulfones, sulfoxides, sulfonimides, sulfinimides, acylsulfonamides and acylsulfinamides of Formula I: n n n n n n n n n n n n wherein R 1 , R 2 , M 1 , M 2 , L, E 1 , E 2 , Q 1 , Q 2 and n are as defined herein, are useful as anti-angiogenesis agents, as agents for treatment of age related senile dementia, and as antiproliferative agents including, for example, as anticancer agents. |