abstract |
(Z)-styryl benzylsulfones of formula I are useful as anticancer agents:whereinR1 is selected from the group consisting of hydrogen, chloro and nitro;R2 is selected from the group consisting of hydrogen, lower alkyl, lower alkoxy, chloro, bromo, iodo and fluoro; andR3 and R4 are independently selected from the group consisting of hydrogen, lower alkyl, nitro, chloro, bromo, iodo and fluoro;provided that at least one of R1 or R2 is hydrogen.The corresponding (Z)-styryl benzylsulfides are useful as intermediates in the preparation of the biologically active (Z)-styryl benzyl sulfones. |