| abstract |
Sulfones of formula (I) are useful as antiproliferative agents, including, for example, anticancer agents, wherein Q¿1' is selected from the group consisting of: (a) a phenyl radical according to formula (II), wherein R¿1?, R2, R3, R4 and R5 are independently selected from the group consisting of hydrogen, halogen, C1-C6 alkyl, C1-C6 alkoxy, nitro, cyano, carboxyl, hydroxyl, amino, C1-C6 trifluoroalkoxy and trifluoromethyl; (b) an aromatic radical selected from the group consisting of 1-naphthyl, 2-naphthyl and 9-anthryl; and (c) an aromatic radical according to formula (III), wherein n1 is 1 or 2, Y1 and Y2 are independently selected from the group consisting of hydrogen, halogen, and nitro, and X1 is selected from the group consisting of oxygen, nitrogen, sulfur; and (F2); and Q2 is selected from the group consisting of: (d) a phenyl radical according to formula (II), as defined above; (e) an aromatic radical selected from the group consisting of 1-naphthyl, 2-naphthyl and 9-anthryl; (f) an aromatic radical according to formula (IV) wherein n1 is 1 or 2, Y3 and Y4 are independently selected from the group consisting of hydrogen, halogen, and nitro, and X2, X3 and X4 are independently selected from the group consisting of carbon, oxygen, nitrogen, sulfur and (F2) provided that not all of X2, X3 and X4 may be carbon; and (g) 1-piperazinyl; provided that at least one of Q1 or Q2 is other than a phenyl radical according to formula (II); or a pharmaceutically acceptable salt thereof. Sulfones of formula (V) are also useful as antiproliferative agents, including, for example, anticancer agents, wherein X is sulfur or oxygen; Ya and Yb are independently selected from the group consisting of hydrogen, halogen, and nitro; and R1-R5 are defined as above; or a pharmaceutically acceptable salt thereof. |