| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_69ece09bafee7e0c49d1f7951a3faa2c |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-467
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 |
| filingDate |
2009-03-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2011-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1c37ec3703b014538b7c74d263499e49
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e9f3ac8cf2ab2e7e35e38cc820320650
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ab32168d45e81d044e6e03750f75be03
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1f4115ab8346c741c6860226b3e5fb31 |
| publicationDate |
2011-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8007795-B2 |
| titleOfInvention |
Anti-tissue factor antibodies and methods of use thereof |
| abstract |
The invention includes antibodies that provide superior anti-coagulant activity by binding native human TF with high affinity and specificity. Antibodies of the invention can effectively inhibit blood coagulation in vivo. Antibodies of the invention can bind native human TF, either alone or present in a TF:FVIIa complex, effectively preventing factor X or FIX binding to TF or that complex, and thereby reducing blood coagulation. Preferred antibodies of the invention specifically bind a conformational epitope predominant to native human TF, which epitope provides an unexpectedly strong antibody binding site. Also provided are humanized antibodies and fragments thereof that bind to the TF. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021163299-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021163298-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021163369-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9920133-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021222587-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2013011389-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11672826-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11730762-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11738052-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008255111-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11401324-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11518792-B2 |
| priorityDate |
2001-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |