| abstract |
The present invention relates to methods and compositions for preventing, inhibiting, or treating metastasis, as well as to methods of making and using such compositions. More particularly, the present invention relates to molecules that bind tissue factor (TF) and disrupt the TF.VIIa complex, thereby inhibiting the onset and progression of metastasis. In addition, the present invention relates to molecules capable of disrupting tissue factor function, or the function of TF.VIIa complexes. The present invention also relates to methods and compositions useful in disrupting or modulating cell-surface TF expression, including, for example, molecules capable of modifying or disrupting transcription and translation of TF-encoding sequences, or molecules which specifically modulate cellular processing or degradation of TF. The present invention also discloses therapeutic compositions and methods for inhibiting or disrupting tumor-host interactions necessary for initiation and maintenance of the metastatic process. |