| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7323408bb1dd9c6e51c5dabd5c47bf4f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ab3a8c3ae369557673cd2044cf8b74bf
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_75340acb75e7522ea270faf62d315b4a |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2730-10122 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6876
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N7-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-51
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-70
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N7-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate |
2007-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2010-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5a7c40156d1c3f005ce88eab791a6f9c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c152e2cee50edfe1f9134cdd840987be
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_07ac7433f2cd8315cd866d34fb8084bb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_970026ce4d0fb8053f6d8e59ec65955a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e147d3a20824ae0a3f5cd64b67c6e8f1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b824bf595335fda03d6d08ba8250d590
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f0f1451134ff782e212e51316d7d0638 |
| publicationDate |
2010-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-7745130-B2 |
| titleOfInvention |
Hepatitis B viral variants with reduced susceptibility to nucleoside analogs and uses thereof |
| abstract |
The present invention relates generally to viral variants exhibiting reduced sensitivity to particular agents and/or reduced interactivity with immunological reagents. More particularly, the present invention is directed to hepatitis B virus (HBV) variants exhibiting complete or partial resistance to nucleoside or nucleotide analogs and/or reduced interactivity with antibodies to viral surface components including reduced sensitivity to these antibodies. The present invention further contemplates assays for detecting such viral variants, which assays are useful in monitoring anti-viral therapeutic regimens and in developing new or modified vaccines directed against viral agents and in particular HBV variants. The present invention also contemplates the use of the viral variants to screen for and/or develop or design agents capable of inhibiting infection, replication and/or release of the virus. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8592143-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010304392-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2014199268-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8729231-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011236422-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8367317-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011033838-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9701982-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010203506-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8211443-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9702005-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009130651-A1 |
| priorityDate |
2002-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |