| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8b9ecd28810db421823f637142302487
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_66bce9cb071741961f540cff6c647803
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d93a3fdd031e483c033ce2641aca024b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_428dff815117552ee70287dd153805cb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1bfdd184fc87b6d32e64449ba1eec237
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_98ac7d4cede02bd3e09838630e8562c7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cc4a2751444c3a6a23737743d5b1c9bf |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2730-10122 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6876
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N7-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-005 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-51
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N7-00 |
| filingDate |
2010-06-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2825f1c5968121e1084c5ba9a7ea2251
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e38a6379afb56b2eadb88845018fa4f8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_da2105d04776737ce21804263b3603cb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9037307dceabf391dfcf93923c8e01b5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7914e47c651e7e591d9b894cbb9e5807
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6a7a3c65e286e4004b1d2475b81732b0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1d68b6566c06265123499c57086d9c14 |
| publicationDate |
2010-12-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2010304392-A1 |
| titleOfInvention |
Hepatitis b viral variants with reduced susceptibility to nucleoside analogs and uses thereof |
| abstract |
The present invention relates generally to viral variants exhibiting reduced sensitivity to particular agents and/or reduced interactivity with immunological reagents. More particularly, the present invention is directed to hepatitis B virus (HBV) variants exhibiting complete or partial resistance to nucleoside or nucleotide analogs and/or reduced interactivity with antibodies to viral surface components including reduced sensitivity to these antibodies. The present invention further contemplates assays for detecting such viral variants, which assays are useful in monitoring anti-viral therapeutic regimens and in developing new or modified vaccines directed against viral agents and in particular HBV variants. The present invention also contemplates the use of the viral variants to screen for and/or develop or design agents capable of inhibiting infection, replication and/or release of the virus. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8592143-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8211633-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8367317-B2 |
| priorityDate |
2002-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |