| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b698c38d420403e7607fcfc918d68aa4 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2730-10122
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-525 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N7-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-706
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-86 |
| filingDate |
2013-02-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b057a2a613a241c73a67342dc51cf6b0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_77b5c960186a6ab69b7e8c82b2ac321e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_59da5a8a947810415e583e1eb9010ae9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d5b48472a3760d050e58986374783793
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c688c8dad137b0b7047fe6401f6ea3f1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_25aaf19836efa3316880981c7819850e |
| publicationDate |
2014-07-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2014199268-A1 |
| titleOfInvention |
Variants of hepatitis b virus with resistance to anti-viral nucleoside agents and applications thereof |
| abstract |
The present invention relates generally to viral variants exhibiting reduced sensitivity to particular agents and/or reduced interactivity with immunological reagents. More particularly, the present invention is directed to hepatitis B virus (HBV) variants exhibiting complete or partial resistance to nucleoside or nucleotide analogs and/or reduced interactivity with antibodies to viral surface components including reduced sensitivity to these antibodies. The present invention further contemplates assays for detecting such viral variants, which assays are useful in monitoring anti-viral therapeutic regimens and in developing new or modified vaccines directed against viral agents and in particular HBV variants. The present invention also contemplates the use of the viral variants to screen for and/or develop or design agents capable of inhibiting infection, replication and/or release of the virus. |
| priorityDate |
2005-04-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |