http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7507812-B2
Outgoing Links
Predicate | Object |
---|---|
assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_38b04dac5e5700071e574cb587f8e099 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D501-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D501-24 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-24 |
filingDate | 2004-09-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2009-03-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_713f0bd48ac9d73ccdd9665dd6b06077 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_967ee82a8a8242e2a7e5946e1dc1be39 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d067848e57b63c33c113db34a0cb6f41 |
publicationDate | 2009-03-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | US-7507812-B2 |
titleOfInvention | Process for producing 3-chloromethyl-3-cephem derivatives |
abstract | An industrially advantageous process for producing 3-chloromethyl-3-cephem derivative crystals. The process for 3-chloromethyl-3-cephem derivative production comprises: a first step in which a thiazolineazetidinone derivative (1) is reacted with a sulfonyl halide (2) in the presence of an acid in a solvent to obtain an azetidinone derivative (3); a second step in which the azetidinone derivative (3) is reacted with a chlorinating agent in an organic solvent to obtain a chlorinated azetidinone derivative (4); and a third step in which the chlorinated azetidinone derivative (4) is reacted with an alcoholate (5) at a pH of 8 or lower in a solvent comprising an alcohol and an ether and a 3-chloromethyl-3-cephem derivative (6) is recovered in the form of crystals. |
priorityDate | 2003-09-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 191.