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filingDate 1983-01-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c389e621b8e14a3115470f4a3440310f
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publicationDate 1984-08-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-S59134779-A
titleOfInvention Preparation of azetidinone derivative
abstract PURPOSE: To prepare an azetidinone derivative useful as an important intermediate of cephalosporin antibiotic substance, in high purity, economically, by reacting a thiazolineazetidinone derivative with sulfonyl bromide in a hydrated organic solvent in the presence of an acid. n CONSTITUTION: The objective compound of formula III can be prepared by reacting the compound of formula I (R 1 is aryl, phenylmethyl, phenoxymethyl, etc.; R 2 is H or carboxyl-protecting group) with the compound of formula II (Ar is phenyl which may have substituent group) in the presence of an acid (e.g. 1W 20% aqueous solution of hydrochloric acid) in a hydrated organic solvent (e.g. methanol) at 0W20°C for 10minW2hr. The molar ratio of the compound of formula I to the compound of formula II is 1:1.0W1.2, and that of the acid to the compound of formula I is 1.0W1.5:1. n COPYRIGHT: (C)1984,JPO&Japio
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