| abstract |
The present invention provides an antitumor agent comprising a staurosporin derivative or a pharmaceutically acceptable salt thereof, as an active ingredient, which is represented by the general formula (I):wherein R<1 >represents hydrogen, hydroxy or lower alkoxy, R<2 >and R<3 >are the same or different and represent hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted lower alkenyl, substituted or unsubstituted lower alkynyl, substituted or unsubstituted aryl, a substituted or unsubstituted heterocyclic group, halogen, nitro, formyl, etc., R<4 >represents hydrogen, etc., R<5 >represents NR<11A>R<12A >(wherein R<11A >and R<12A >represent hydrogen, substituted or unsubstituted lower alkyl, etc.), provided that R<2 >and R<3 >are not simultaneously hydrogen. |