| abstract |
Described are compounds of formula (I), wherein X is methylene, carbonyl or hydroxymethylene, R0 is oxygen or N-OR1; R1 is hydrogen, alkyl, cycloalkyl, aralkyl, acyl, SO2-Ra, or carboxyalkyl; Ra is lower alkyl, cycloalkyl; R2 is hydrogen, lower alkyl, cycloalkyl or acyl; R3 is hydrogen, halogen, amino, alcyl, alkyl, cycloalkyl, alkoxyalkyl or aralkyl; R4 and R5 independent of each other are hydrogen, hydroxy, nitro, amino, lower alkyl, cycloalkyl, lower alkoxy, carbamoyl or halogen; and R6 is hydrogen or nitro, excluding the compound wherein X is methylene, R0 is N-OH, R2 is methyl and R3, R4, R5 and R6 are hydrogen, and salts thereof, a process for the preparation of this type of compounds including staurosporin-4'-one oxime, pharmaceutical compositions comprising these compounds and the preparation thereof, and the use of these compounds and compositions for the theraputic treatment of the human or animal body. |