| abstract |
PCT No. PCT/EP95/01909 Sec. 371 Date Nov. 27, 1996 Sec. 102(e) Date Nov. 27, 1996 PCT Filed May 19, 1995 PCT Pub. No. WO95/32974 PCT Pub. Date Dec. 7, 1995The utility of known and novel staurosporin derivatives of formula I <IMAGE> (I) wherein R1 is formyl, an aliphatic hydrocarbon radical having up to 29 carbon atoms that is unsubstituted or substituted by aryl, or is an aryl radical, R2 is hydrogen, C1-C5alkyl, benzoyl, lower alkanoyl or alpha -aminoacyl having a free or protected amino group, and R3 is hydrogen, hydroxy, lower alkoxy or oxo, or wherein R1 is methoxycarbonylmethyl, R2 is benzoyl, and R3 is hydrogen, for avoiding or removing multi-drug resistance to anti-tumour agents, such as vinblastine or adriamycin, is described. |