| abstract |
Azetidinone derivatives of formula (I) in which R 1 and R 2 , which may be the same or different, is each selected from hydrogen or C.sub.(1-8) alkyl; R 3 is C.sub.(1-8) alkyl or C.sub.(3-8) cycloalkyl each of which may be optionally substituted; X is a linker group; Y is an aryl group; and n is 0, 1 or 2; and excluding benzyl (4-methylthio-2-oxo-azetidin-1-yl)acetate are inhibitors of the enzyme Lp PLA2 and are of use in therapy, in particular treating atherosclerosis. |