| abstract |
A pharmaceutical preparation comprising an antibiotic, a pharmaceutical excipient therefor, and in addition an oxapenem-3-carboxylic acid of the formula <IMAGE> or a pharmaceutically acceptable salt, ester or amide in which R1 and R2 each independently is hydrogen or a pharmaceutically acceptable group having 1 to 10 carbon atoms which is connected with the balance of the molecule via carbon-carbon single bonds, and in which R3, R4 and R5 each independently is a pharmaceutically acceptable group having 1 to 10 carbon atoms which is connected with the balance of the molecule via carbon-carbon single bonds. |