abstract |
The present invention provides compositions and methods useful for treating and preventing neurodegenerative diseases and neurologically related disorders by inhibiting Lp-PLA 2 . Such compositions and methods can be used to treat and prevent diseases and disorders that exhibit abnormal blood brain barrier (BBB) function, such as neurodegenerative diseases with transmissible BBB, such as Alzheimer's disease, Huntington's disease, Parkinson's disease, and vascular dementia . |