| abstract |
The present invention relates to compounds of the formula:R1SCH(R2)CH(R3)CO-AA1[AA2]m[AA3]n-X orHSCH2[CH2CH(CH3)2]CO-Nal-NH2wherein Nal is L-3-(2-naphthyl)alanine; m is the integer 0 or 1; n is an integer from 0-2; AA1 is a non-polar hydrophobic aromatic amino acid; AA2 is alanine, glycine, leucine, isoleucine or phenylalanine; AA3 is one of the twenty naturally occurring amino acids, preferably glutamine or arginine; R1 is hydrogen, alkyl having from 1-10 carbon atoms, alkanoyl having from 2-10 carbon atoms, or aroyl having from 7-10 carbon atoms; R2 is hydrogen or alkyl having from 1-6 carbon atoms; R3 is hydrogen, alkyl having from 2-10 carbon atoms, cycloalkyl having from 3-6 carbon atoms, aryl or arylalkyl, wherein aryl moieties have from 6-10 carbon atoms; X is NH2, OH, OCH3 or OCH2CH3; and salts thereof. |