| abstract |
The disclosure relates to novel synthetic thiopeptolide substrates having high activity for the enzyme collagenase. These substrates have the following amino acid sequences:whereinR = H or N-protecting group,X = Leu, lle, Phe, Val, Gln, Ala,Y = Leu, lle, Phe, Val, Ala,Z = Leu, lle, Phe, Val, Gin, Ala, andR, = terminal amide, carboxyl or ester group. |