| abstract |
There is disclosed a compound having the formula: herein the core moiety is a heterocylic moiety wherein Ca, Cb, and Cc are an R or S enantiomer or racemic mixture and the Ca, Cb, and Cc carbon atoms are bonded together by a single bond, double bond, ether or ester linkages, wherein R1, R2 and R3 are independently halo, hydroxy, hydrogen, keto, isothiocyano, azide or haloacetoxy with the proviso that at least one of R1, R2 or R3 must be a halo, isothiocyano, azide or haloacetoxy group, wherein R4 is hydrogen, C1-6 alkyl, C1-6 alkenyl, cyclo C4-6 alkyl, or phenyl, and wherein halo refers to fluoro, chloro, bromo and iodo and salts thereof and pharmaceutical compositions thereof. |