| abstract |
Compound of the formula (I) <IMAGE> (I) wherein n is zero or an integer of 1 to 3; R is (a) -NHR3, wherein R3 is (a') -CON(NO)R4, in which R4 is C1-C4 alkyl either unsubstituted or substituted by halogen; or (b') -CO(CH2)m-R5, in which R5 is halogen, oxiranyl, methyloxiranyl, aziridinyl, a group <IMAGE> or a group <IMAGE> and m is zero or an integer of 1 to 4; or (b) <IMAGE> wherein either R6 and R7 are the same and are each oxiranemethyl, aziridinemethyl, or C2-C4 alkyl 2-substituted by halogen or by a group -OSO2R8 wherein R8 is C1-C4 alkyl or phenyl, or one of R6 and R7 is hydrogen and the other is as defined above; each group R1 is, independently, hydrogen or C1-C4 alkyl; R2 is a C1-C6 alkyl group terminating with (i) a basic moiety chosen from an amino group, a mono- or di- C1-C6 alkylamino group, an amidino group, a group <IMAGE> imidazolyl, imidazolinyl, tetrahydropyrimidinyl and oxazolidinyl; or (ii) a carboxy group; or (iii) a free hydroxy group -OH or a glycosilated hydroxy group -OD wherein D is a glucose, mannose or ribose sugar residue or the daunosamine amino-sugar residue; with the proviso that n is different from one when R2 is <IMAGE> and the pharmaceutically acceptable salts thereof. The compounds are useful as antiviral and antitumor agents. |