| abstract |
Methods are disclosed for inhibiting the infectivity of HIV-1 in human cells. The methods comprise contacting human cells infected with HIV-1, with certain quinolinyl and acridinyl derivatives, including amodiaquin, chloroquine, hydroxychloroquine, primoquine, quinacrine and compounds having the formula: ##STR1## wherein R 1 and R 2 are each hydrogen, or join to form a cyclic structure of the formula: ##STR2## and R 3 and R 4 , same or different, are hydrogen, C 1 -C 8 lower alkyl or hydroxy substituted C 1 -C 8 lower alkyl, and the pharmaceutically acceptable salts thereof. |