| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4c3c65b018ce7acd6572dcfe1fbf8e0c |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2740-16122 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-56972
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-56988
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2812 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-569 |
| filingDate |
2005-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c51979d4d8feecf56f81a6272050d612
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a768e5d04eb0623e2fc5c99ccc216faa
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3fa84e73800fe91c95423fdb70f4514f |
| publicationDate |
2006-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2006140977-A1 |
| titleOfInvention |
Methods for assaying inhibition of HIV-1 envelope glycoprotein-mediated membrane fusion |
| abstract |
This invention provides: agents determined to be capable of specifically inhibiting the fusion of a macrophage-tropic primary isolate of HIV-1 to a CD4 + cell, but not a T cell-tropic isolate of HIV-1 to a CD4 + cell; and agents determined to be capable of specifically inhibiting the fusion of a T cell-tropic isolate of HIV-1 to a CD4 + cell, but not a macrophage-tropic primary isolate of HIV-1 to a CD4+ cell. This invention also provides: agents capable of specifically inhibiting the fusion of a macrophage tropic primary isolate of HIV-1 with a CD+ cell susceptible to infection by a macrophage-tropic primary isolate of HIV-1; and agents capable of specifically inhibiting the fusion of a T cell-tropic isolate of HIV-1 with a CD 4 + cell susceptible to infection by a T cell-tropic isolate of HIV-1. The agents include but are not limited to antibodies. This invention further provides: methods of inhibiting fusion of a macrophage-tropic primary isolate of HIV-1 with a CD+ cell susceptible to infection by a macrophage-tropic primary isolate of HIV-1 which comprises contacting the CD4 + cell with an amount of an agent capable of specifically inhibiting such fusion so as to thereby inhibit such fusion; and methods of inhibiting fusion of a T cell-tropic isolate of HIV-1 with a CD4 + cell susceptible to infection by a T cell-tropic isolate of HIV-1 which comprises contacting the CD4 + cell with an amount of an agent capable of specifically inhibiting such fusion so as to thereby inhibit such fusion. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7666419-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011135634-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007231327-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8821877-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007048820-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008241135-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7901685-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006233798-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7862994-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7736649-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7851600-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2002155429-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7345153-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007020280-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7858298-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011200592-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006194244-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2002045161-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008107595-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007026441-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006029932-A1 |
| priorityDate |
1995-06-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |