| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4c3c65b018ce7acd6572dcfe1fbf8e0c |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-70514 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-73
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-16 |
| filingDate |
2000-01-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2004-02-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d6ee59a279df0f8fc79776f2196681e8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c51979d4d8feecf56f81a6272050d612 |
| publicationDate |
2004-02-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-6692745-B2 |
| titleOfInvention |
Compositions and methods for inhibition of HIV-1 infection |
| abstract |
This invention provides a composition which comprises an admixture of two compounds, wherein one compound retards attachment of HIV-1 to a CD4+ cell by retarding binding of HIV-1 gp120 envelope glycoprotein to CD4 on the surface of the CD4+ cell and the other compound retards gp41 from adopting a conformation capable of mediating fusion of HIV-1 to a CD4+ cell by binding noncovalently to an epitope on a gp41 fusion intermediate, wherein the relative mass ratio of the compounds in the admixture ranges from about 100:1 to about 1:100, the composition being effective to inhibit HIV-1 infection of the CD4+ cell. This invention also provides a method of inhibiting HIV-1 infection of a CD4+ cell which comprises contacting the CD4+ cell with an amount of the above composition effective to inhibit HIV-1 infection of the CD4+ cell so as to thereby inhibit HIV-1 infection of the CD4+ cell. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007020280-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006233798-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011135634-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2002155429-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2586461-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7736649-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007048820-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008015348-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3187585-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007231327-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7851600-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2679596-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2568289-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7862994-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7858298-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7901685-B2
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http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8821877-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2848937-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2873423-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3072901-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3069730-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7666419-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008107595-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008241135-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012170765-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008138897-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008226651-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008187539-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009155774-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004062767-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2002106374-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7935797-B2 |
| priorityDate |
2000-01-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |