| abstract |
An angiotensin II antagonist of the formula: <IMAGE> in which: Rp1 represents hydrogen, C1-C6 alkyl, C3-C6 cycloalkyl or C1-C6 alkanoyl; Rp2 represents a single bond, C1-C4 alkylene or C1-C4 alkylidene; Rp3 and Rp4 are independently selected from the group consisting of hydrogen and C1-C6 alkyl; Rp5 represents hydrogen, C1-C4 alkyl, phenyl, naphthyl, benzyl, diphenylmethyl, naphthylmethyl, alkanoyloxyalkyl, cycloalkanecarbonyloxyalkyl, alkoxycarbonyloxyalkyl, cycloalkyloxycarbonyloxyalkyl, (5-phenyl-2-oxo-1,3-dioxolen-4-yl)methyl, (5-alkyl-2-oxo-1,3-dioxolen-4-yl)methyl or phthalaidyl; Rp6 represents a carboxy or a tetrazol-5-yl; and Xp represents an oxygen or sulfur, and pharmaceutically acceptable salts thereof. The compounds have hypotensive activity and can thus be used for the treatment and prophylaxis of hypertension. |