abstract |
Water-soluble prodrugs of the formula: <IMAGE> (I) wherein: D is a biologically active nucleophile; M is X or Q; x is an electron withdrawing group; Q is a moiety containing a free electron pair positioned five or six atoms from Y'; Y and Y' are oxygen or sulfur; R is a polyalkylene oxide; and Z is OH, C1-4 alkyl moieties or <IMAGE> are disclosed. |