| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f9c9410104fff84049bb17df9d762a53 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08G63-688
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-13 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G65-334
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-555
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G63-50 |
| filingDate |
2006-02-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2009-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5155a59c0bce923c977a9736f4ba1fb0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8eda95ace13dc2adc42c07329d9ce878 |
| publicationDate |
2009-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-7511095-B2 |
| titleOfInvention |
Thioester-terminated water soluble polymers and method of modifying the N-terminus of a polypeptide therewith |
| abstract |
The invention provides reagents and methods for conjugating a polymer specifically to the α-amine of a polypeptide. The invention provides monofunctional, bifunctional, and multifunctional PEGs and related polymers having a terminal thioester moiety capable of specifically conjugating to the α-amine of a polypeptide having a cytokine or histidine residue at the N-terminus. The invention provides reactive thioester-terminated PEG polymers that have suitable reactivity with an N-terminal cysteine or histidine residue of a polypeptide to produce an amide bond between the PEG molecule and the polypeptide. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9415115-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8071678-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9005598-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11116816-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10420819-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011065862-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7834088-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10406202-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8329876-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10702574-B2 |
| priorityDate |
2001-10-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |