http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5530161-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_80543d0a7ce91a89b82fd589016b9b65 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C327-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C323-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C317-44 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C323-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C317-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C327-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-34 |
| filingDate | 1994-02-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1996-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_780cebc999111219ab12de055c3d6141 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f8c1ba0f6702abba9280b0c71b98dc2f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_702bdbb96ba89fededc9abf32c0be91e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_17eb147ce4355c8608e96c656aa0ad83 |
| publicationDate | 1996-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-5530161-A |
| titleOfInvention | Hydroxamic acid based collagenase inhibitors |
| abstract | Compounds of general formula I: <IMAGE> (I) wherein: R1 represents a C1-C6 alkyl, phenyl, thiophenyl, substituted phenyl, phenyl(C1-C6)alkyl, heterocyclyl, (C1-C6)alkylcarbonyl phenacyl or substituted phenacyl group; or, when n=O, R1 represents SRx, wherein Rx represents a group: <IMAGE> R2 represents a hydrogen atom or a C1-C6 alkyl, C1-C6 alkenyl, phenyl(C1-C6)alkyl, cycloalkyl(C1-C6)alkyl or cycloalkenyl(C1-C6)alkyl group; R3 represents an amino acid residue with R or S stereochemistry or a C1-C6 alkyl, benzyl, (C1-C6alkoxy)benzyl or benzyloxy(C1-C6 alkyl) group; R4 represents a hydrogen atom or a C1-C6 alkyl group; R5 represents a hydrogen atom or a methyl group; n is an integer having the value 0, 1 or 2; and A represents a C1-C6 hydrocarbon chain, optionaly substituted with one or more C1-C6 alkyl, phenyl or substituted phenyl groups; and their salts and N-oxides are collagenase inhibitors are and useful in the management of disease involving tissue degradation and/or the promotion of wound healing. Diseases involving tissue degradation include arthropathy (particularly rheumatoid arthritis), inflammation, dermatological diseases, bone resorption diseases and tumor invasion. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007276010-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7671072-B2 |
| priorityDate | 1991-07-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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