| abstract |
The present invention relates to a new family of chemical compounds having pharmacological activity, in particular a collagenase inhibitor, a process for the production of these compounds and pharmaceutical compositions containing them.n n n -W représente un reste d'acide aminé choisi parmi la valine, la lysine, la norleucine et la méthionine ; et -Z représente un radical amino ou alcoylamino dont la partie alcoyle qui contient 1 ou 2 atomes de carbone est substituée par un radical phényle ou triflumrophényle, et comprennent également leurs dtastéréoisomérès et leurs sels d'addition avec les acldes pharmaceutiquement acceptables. According to the intention, these compounds correspond to the general formula in which -W represents an amino acid residue chosen from valine, lysine, norleucine and methionine; and -Z represents an amino or alkylamino radical, the alkyl part of which contains 1 or 2 carbon atoms is substituted by a phenyl or triflumrophenyl radical, and also include their dtastereoisomers and their pharmaceutically acceptable addition salts with acldes. n n n The intention finds particular application in the pharmaceutical industry. |