| abstract |
PCT No. PCT/GB93/02331 Sec. 371 Date May 12, 1995 Sec. 102(e) Date May 12, 1995 PCT Filed Nov. 12, 1993 PCT Pub. No. WO94/10990 PCT Pub. Date May 26, 1994The present invention is directed to the method of inhibiting the release of tumor necrosis factor (TNF) in a condition mediated by TNF by administration of certain hydroxamic add derivatives, also known as matrix metalloproteinase inhibitors, and thus the method of this invention is useful in the management of diseases or conditions mediated by TNF. |