| abstract |
PCT No. PCT/JP93/00961 Sec. 371 Date May 19, 1994 Sec. 102(e) Date May 19, 1994 PCT Filed Jul. 12, 1993 PCT Pub. No. WO94/02452 PCT Pub. Date Mar. 2, 1994.The present invention provides a novel benzene derivative useful as a preventive and medically treating medicine for arteriosclerosis, and a cholesterol O-acyl transferase inhibitor comprising the benzene derivative as an active ingredient. The benzene derivative according to the present invention is represented by the following general formula (I): <IMAGE> (I) wherein R1 represents a carboxyl group which may be protected or a group represented by the formula: <IMAGE> wherein R5 represents a lower alkyl group or a hydroxyalkyl group and R6 represents a hydrogen atom or a hydroxyl group; R2 represents a hydrogen atom, a lower alkyl group or the like; R3 and R4 each represent a hydrogen atom or a hydroxyl group; and p is an integer of 1 to 6. |