| abstract |
Hypolipidemic and atherosclerotic compounds have the formulae <IMAGE> wherein R' is a branched or unbranched mono- or polyunsaturated or cyclopropylated C3-C22 alkyl group; R is H or a group convertible thereto in vivo; Z is a> <IMAGE> wherein D is H, OH or a substituted or unsubstituted loweralkyl, loweralkoxy, benzyloxy, phenoxy or 3-pyridyloxy (substituents defined in the specification) b> <IMAGE> wherein B is a saturated or unsaturated lower alkylene group and E is selected from hydrogen, loweralkyl, loweralkoxyethyl, diloweralkylaminoethyl, (mono- or polyhydroxy) loweralkyl, (mono- or polycarboxy) loweralkyl, (mono- or polycarboxy) hydroxyloweralkyl, allyl, 2,3-epoxypropyl, substituted or unsubstituted (phenyl, benzyl or 3- pyridyl), pyridylmethyl, and tetrahydropyranyl; or c> <IMAGE> wherein R4 and R5 are selected from H or certain specified hydrocarbon, oxygen-, sulphur- or nitrogen- containing groups or may together form specified rings; and R6 and R7 are the same or different and are selected from loweralkyl, (mono- and polyhydroxy) loweralkyl, carboxyloweralkyl, sulfo loweralkyl, sodium sulfo loweralkyl, and, when taken together, loweralkylene; and include the pharmaceutically acceptable salts thereof. |