| abstract |
Compounds of formula (I): <IMAGE> (I) in which: X represents -CH2-, -(CH2)2-, -CH=CH-, -O-CH2-, -S-CH2-, -SO-CH2- or -SO2-CH2-, Y represents oxygen or sulfur or -NR6-, R1 represents hydrogen or linear or branched (C1-C6) alkyl, R2 represents hydrogen or halogen, linear or branched (C1-C6) alkyl, (substituted or unsubstituted), hydroxyl, linear or branched (C1-C6) alkoxy or linear or branched (C1-C6) alkylthio, R3 represents hydrogen or halogen, linear or branched (C1-C6) alkyl (substituted or unsubstituted), hydroxyl, linear or branched (C1-C6) alkoxy or linear or branched (C1-C6)alkylthio, R4 represents hydrogen (on condition that, in this case, R1 represents hydrogen), halogen, linear or branched (C1-C6) alkyl (substituted or unsubstituted) or hydroxyl, or alternatively R1 and R2, R2 and R3, R3 and R4 or R4 and X, together with the carbon atoms which bear them, form a benzene ring, on condition that, in the case where R1 and R2 form a benzene ring, X is other than -CH2- or -(CH2)2-, R5 represents hydrogen or amino (substituted or unsubstituted), R6 has the same meaning as R1, their isomers and also their. addition salts with a pharmaceutically acceptable acid and medicinal product containing the sarne are useful as partial alpha 1 and alpha 2 adrenergic agonist in the treatment of venous disease and migraine. |