| abstract |
Compounds of formula (I): <IMAGE> (I) in which: X represents -CH2-, -(CH2)2-, -CH=CH-, -O-CH2-, -S-CH2-, -SO-CH2- or -SO2-CH2-, Y represents oxygen or sulfur or -NR5-, R1 represents halogen, linear or branched (C1-C6) alkyl (unsubstituted or substituted), hydroxyl or linear or branched (C1-C6) alkoxy, R2 represents hydrogen or halogen, linear or branched (C1-C6) alkyl (unsubstituted or substituted), hydroxyl, linear or branched (C1-C6) alkoxy or linear or branched (C1-C6) alkylthio, R3 represents hydrogen or halogen, linear or branched (C1-C6) alkyl (unsubstituted or substituted), hydroxyl, linear or branched (C1-C6) alkoxy or linear or branched (C1-C6) alkylthio, R4 represents hydrogen or amino (unsubstituted or substituted) R5 represents hydrogen or linear or branched (C1-C6) alkyl, or alternatively R1 and R2 form, together with the carbon atoms which bear them, a benzenic ring, on condition that, in this case, X represents -CH2- or -(CH2)2-, their isomers and their addition salts with a pharmaceutically acceptable acid, and medicinal product containing the same are useful as alpha 2-adrenergic agonist. |