| abstract |
Compounds of the formula <IMAGE> Formula I wherein Alk is lower-alkylene; R1 is hydrogen, lower-alkyl, Ar or ArCOO; R2 is hydrogen or lower-alkyl; R3 and R4 are the same or different hydrogen, fluoro, chloro, bromo, hydroxy, lower-alkoxy, lower-alkyl, or trifluoromethyl; Ar is phenyl, naphthyl, anthryl, 2-phenylethenyl or a 5- or 6-membered monocyclic or 9- or 10-membered bicyclic fused aromatic heterocyclic ring containing carbon and one or two heteroatoms independently selected from oxygen, nitrogen and sulfur, or such carbocyclic or heterocyclic rings substituted with from 1 to about 3 of lower-alkoxy, lower-alkyl, lower-alkylthio, lower-alkyl sulfinyl, lower-alkyl sulfonyl, hydroxy, cyano, amino, lower-alkylamino, dilower-alkylamino or halo; or pharmaceutically acceptable acid addition salts thereof are useful as analgesics and in the treatment of glaucoma. |