| abstract |
PCT No. PCT/JP86/00155 Sec. 371 Date Aug. 15, 1986 Sec. 102(e) Date Aug. 15, 1986 PCT Filed Mar. 31, 1986 PCT Pub. No. WO86/05779 PCT Pub. Date Oct. 9, 1986.Novel phenylene derivatives shown by the general formula <IMAGE> wherein A represents a hydrogen atom, a phenyl group or a phenoxy group, n represents an integer of 3 to 10, R1 represents a hydrogen atom or a lower alkoxy group, X1 represents -CH2CH2-, -CH=CH-, -CONH-, &cir& B represents <IMAGE> (wherein R2 represents a hydrogen atom, a halogen atom, a nitro group, etc.), <IMAGE> (wherein R3 represents a hydrogen atom, a hydroxyl group or a lower alkoxy group), X2 represents -CH=CH-, -CH2CH2-, etc. and D represents a carboxy group, a lower alkoxycarbonyl group or <IMAGE> which are useful as drugs, particularly SRS-A (slow reacting substance of anaphylaxis) antagonist, i.e. they are useful as prophylaxis and treatment for various allergic diseases (e.g. bronchial asthma, allergic rhinitis, urticaria) or, ischemic heart diseases, inflammation, etc. induced by SRS-A. |