| abstract |
A novel (fused) benz(thio)amide of the general formula: <IMAGE> or a non-toxic salt thereof, wherein R4 represents: (i) when B represents a closed ring, a group of the general formula: U(CH2)nCOOR8 <IMAGE> (CH2)pCOOR8 or <IMAGE> wherein U represents an oxygen atom or a sulfur atom; or (ii) when B represents a divalent group, a group of the general formula: (CH2)pCOOR8 or <IMAGE> wherein R5, R6, R7, R8, n, m, p and q are as defined in the specification, and exclusing certain compounds as defined in the specification, depending on whether A represents a single bond or a group. The compounds are useful for the prevention and/or treatment of diseases induced by leukotrienes, 5 alpha -reductase, phospholipase and aldose reductase in mammals, especially human beings. |