| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f62fc4967811f8e8b3165e7e2612155a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fb2f2acd00344d63758e9a28c32fc49a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6fc49a7131894339046e6752df7c0e3b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a02a33027a2016d10d575f7a43b1a1c6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7f5542c1a7d7595ed640bef532973e1a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dfc98b6d781f751c2ebb2f7dc8633695 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-7028
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2510-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-52 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M23-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-574
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5091
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0694 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 |
| filingDate |
2013-03-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f0b3a4a9555d867afaec3cb36da0a720
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c9a6f4cf7d56807229e07beba07656b6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_99fe4af931bc7cb971ce93f8016c7807
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e640616f9bdfe4485dfa3744311b337e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_61e918e8030849ae231cf5794e91d9a8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d8b04e5ba629cda647e93765fceb9cd8 |
| publicationDate |
2014-09-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2014274953-A1 |
| titleOfInvention |
Ex vivo human multiple myeloma cancer niche and its use as a model for personalized treatment of multiple myeloma |
| abstract |
The described invention provides an ex vivo dynamic multiple myeloma (MM) cancer niche contained in a microfluidic device. The dynamic MM cancer niche includes (a) a three-dimensional tissue construct containing a dynamic ex vivo bone marrow (BM) niche, which contains a mineralized bone-like tissue containing viable osteoblasts self-organized into cohesive multiple cell layers and an extracellular matrix secreted by the viable adherent osteoblasts; and a microenvironment dynamically perfused by nutrients and dissolved gas molecules; and (b) human myeloma cells seeded from a biospecimen composition comprising mononuclear cells and the multiple myeloma cells. The human myeloma cells are in contact with osteoblasts of the BM niche, and the viability of the human myeloma cells is maintained by the MM cancer niche. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10767164-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017079646-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10317395-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114752567-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021067338-A1 |
| priorityDate |
2013-03-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |