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filingDate 2016-11-04-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2017-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2017079646-A1
titleOfInvention An efficient, scalable patient-derived xenograft system based on a chick chorioallantoic membrane (cam) in vivo model
abstract Embodiments of the disclosure encompass systems that utilize chick chorioallantoic membranes (CAM) as models for cancer xenografts, including at least patient-derived xenografts (CAM-PDX). In particular embodiments, the system employs the CAM-PDX to graft and culture different types of tumor tissue on a single or multiple eggs. In specific embodiments multiple tumor regions of a single tumor are cultured on a single egg. Frozen tissue is successfully revived, in specific embodiments. Downstream applications following successful establishment of CAM-PDX models are encompassed.
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