| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ed9109d9869aab4474827be4fab9c22b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_836685cf20ba809e1221378f37551b9e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2975f937084aa4949d6a8bcb97f53bbc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1c1cc907d71e11ce83d05835eb7b3786
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bc9f3089ceaef11ae231f37a6e58576b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5bf8cb14f0800d93d5066a62f5604219 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-55
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-003
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-006
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2800-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-85
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-008
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-002 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-85 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-071
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-79 |
| filingDate |
2007-11-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aab1195a44123302092aa074c8092bca
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_083187685db2dafdec32efa5c2a5e816
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2780e0288ea5dc7a37cc2efba9f2242f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_591c0cd692bef3b9b9a7756e1c29c584
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1e5bee1a26ed59c799b872ea096050f8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_92c48cf906f260c7bd2b95ad7059aa81 |
| publicationDate |
2010-11-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2010285584-A1 |
| titleOfInvention |
Engineered cellular pathways for programmed autoregulation of differentiation |
| abstract |
The present invention provides compositions and methods for programming mammalian cells to perform desired functions. In particular, the present invention provides compositions and methods for programming stem cells to differentiate into a desired cell type. A quorum sensing systems that regulates the expression of cell fate regulators is introduced into mammalian host cells, such as stem cells. The quorum sensing systems generally comprises vectors that express the components of a bacterial quorum sensing pathway, including proteins which catalyze the synthesis of an autoinducer and a gene encoding a regulatory partner of the autoinducer, and vectors in which genes encoding cell fate regulators are operably linked to a promoter induced by the autoinducer/regulatory partner complex. The system can also comprise vectors in which genes encoding additional cell fate regulators are operably linked to a promoter that is induced by a factor synthesized in response to a first stage of differentiation, so that a second stage of differentiation is triggered. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-102354131-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10767164-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111499759-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023050644-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20160056149-A |
| priorityDate |
2006-11-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |