abstract |
Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics and pruritic agents are provided. n The compounds of formulae I, II, III and IV have the structure: n n n wherein n X, X 4 , X 5 , X 7 , X 9 ; n R 1 , R 2 , R 3 , R 4 ; and n Y, Z and n are as described in the specification |